Did you make any progress?
Nope, see below.
And, if you are interested in learning about audio settings, the following thread is excellent:
http://communications.support/threads/75-Motorola-ASTRO25-Optimize-your-audio-settings?
I have refereed to that thread several times in the past. It is indeed a wealth of knowledge.
A legit FW refresh to R20.01.00 and an autotune would be in order at this point, regardless.
I am thinking the same, although I had that done to the last radio that had this issue, and it did not help. See below.
Nope. Although he is pretty close to me, and I had him do a firmware upgrade (Legit Ibutton, I just checked :cop

and alignment on the first radio that exhibited this (For far less that he asks on ebay) and it did not help.
Ok, here is the state of things.
Disabling AGC, noise reduction, and TX emphasis did not help.
The issue is worst about the first second of the transmission, and gets better from there. It's almost like something has to settle. This also seems to fit with the fact that it issue is worse on a keyup right after the radio is turned on, or has been sitting idle for a while. If keyed again right after transmitting, it not nearly as bad.
It is markedly worse on narrowband, than on wideband. On wideband, you only hear it if you are looking for it. On narrowband, you will notice that something is wrong. I can make a recording of the two if you think it would help.
Unlike the previous radio, it is equal across the band, (Last radio was really bad in the 460s, but was almost fine on the 440 band.
I got a private message from another member here, who I have no reason to mis-trust. He had a not so pleasant transaction with the seller, although he does have great FB on Batlabs, so I'm not sure what to think.
Matt